Clinical trial billing is a complex process that requires coordination between research teams, revenue cycle staff, and compliance professionals to ensure accurate billing and regulatory compliance. This session will provide an overview of clinical trial billing fundamentals, including Medicare Coverage Analysis, routine costs, billing grid development, and common compliance risks. The session will also explore the emerging role of artificial intelligence in research billing operations, including opportunities to improve efficiency, automate workflows, enhance audit readiness, and support Medicare Coverage Analysis. The discussion will highlight both the potential benefits and limitations of AI, with a focus on maintaining regulatory compliance, data integrity, and human oversight in an evolving healthcare landscape.