This session guides attendees through the pivotal changes introduced in the 2026 OPPS final rule, highlighting how these updates directly impact outpatient facility coding, reimbursement, and compliance strategies. We’ll dive into the phase-out of the Inpatient-Only (IPO) list — particularly the removal of 285 musculoskeletal procedures in 2026 — and CMS’ exemption of these services from certain medical review policies, including the two-midnight rule. Additionally, the session will cover the accelerated 340B payment offset: an increase from a 0.5 percent to a 2 percent reduction in the OPPS conversion factor for non-drug items and services, excluding hospitals that enrolled in Medicare after January 1, 2018. We’ll also examine the un-packaging of skin substitutes from procedural services into separate APC billing categories and additional policy shifts (such as payment rate updates, quality reporting changes, and pricing transparency expectations) that shape the outpatient coding landscape.